| ncRNA name | TLR2 siRNA |
| ncRNA Category | siRNA |
| Disease name | diabetic retinopathy (DR) |
| Species | Homo sapiens |
| Tissues/Cell_line | human microvascular retinal endothelial cells (HMVREC) |
| Methods | siRNA transfection, Western blot, RT-PCR, ELISA |
| Expression pattern | associated |
| Functional description | HG (25 mM) significantly induced TLR2 and TLR4 mRNA and protein in HMVRECs. It also increased both MyD88 and non-MyD88 pathways, nuclear factor-κB (NF-κB), biomediators, and monocyte adhesion. This inflammation was attenuated by TLR-4 or TLR-2 inhibition, and dual inhibition by a TLR inhibitory peptide as well as TLR2 and 4 siRNA. |
| PubMed ID | 25610879 |
| Year | 2015 |
| Title | Hyperglycemia induces Toll-like receptor-2 and -4 expression and activity in human microvascular retinal endothelial cells: implications for diabetic retinopathy. Rajamani U1, Jialal I2. |
| Drug-related ncRNA | NO |
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